Precious metal-transition metal composite catalyst as well as preparation method and application thereof

The invention provides a noble metal-transition metal composite catalyst as well as a preparation method and application thereof, and belongs to the field of immunotherapy. The composite catalyst shows excellent peroxidase and oxidase simulation activity, and has super strong active oxygen generation capability. The composite catalyst can induce endoplasmic reticulum stress and cell apoptosis related to the endoplasmic reticulum stress, and can significantly enhance the immunogenicity of tumors and activate immune response by inducing immunogenic cell death, promoting T cell infiltration and dendritic cell maturation, stimulating inflammatory factor release and the like; and primary and metastatic tumors are inhibited in cooperation with immune checkpoint blocking drugs. 本发明提供了一种贵金属-过渡金属复合催化剂及其制备方法和应用，属于免疫治疗领域。该复合催化剂表现出优异的过氧化物酶和氧化酶模拟活性，具有超强的活性氧生成能力。该复合催化剂能够诱导内质网应激和内质网应激相关的细胞凋亡，可通过诱导免疫原性细胞死亡、促进T细胞浸润和树突状细胞成熟、刺激炎症因子释放等途径显著增强肿瘤的免疫原性，激活免疫反应，与免疫检查点阻断药物协同抑制原发和转移性肿瘤。