Functional screening using droplet-based microfluidics

The present invention provides a droplet-based microfluidic platform for functional screening of interacting molecules. The platform is particularly useful for high throughput screening of interacting proteins, such as antibodies or engineered cytokines, that trigger detectable downstream signaling...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHEN BINGQING, JIN RUINA, SCHWEIZER LUKAS, HUANG MENGSHI, WANG YUAN, ZHANG HONGKAI
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The present invention provides a droplet-based microfluidic platform for functional screening of interacting molecules. The platform is particularly useful for high throughput screening of interacting proteins, such as antibodies or engineered cytokines, that trigger detectable downstream signaling events. 本发明提供了一种基于液滴的微流体平台,其用于相互作用的分子的功能筛选。该平台特别适用于高通量筛选相互作用的蛋白质,如抗体或工程化细胞因子,这些蛋白质会触发可检测的下游信号传导事件。