Detection marker and kit for identifying non-small cell lung cancer histological subtype

The invention relates to a detection marker and a kit for identifying histological subtypes of non-small cell lung cancer. The detection marker is used for detecting the methylation degree of one or more of human chromosomes chr20: 47444720-47444924, chr20: 47444217-47444339 or chr20: 47444014-47444136 and the combination of the human chromosomes. According to the invention, a methylation gene sequence capable of distinguishing adenocarcinoma and squamous carcinoma in non-small cell lung cancer is found through high-throughput sequencing and a fixed-point methylation fluorescent quantitative PCR (Polymerase Chain Reaction) method. 本发明涉及检测标志物及鉴别非小细胞肺癌组织学亚型的试剂盒，本发明检测标志物包括检测人染色体chr20:47444720-47444924、chr20:47444217-47444339或chr20:47444014-47444136一种或多种及其组合的甲基化程度。本发明通过高通量测序，以及定点甲基化荧光定量PCR方法，发现了可以区分非小细胞肺癌中的腺癌和鳞癌的甲基化基因序列。