Triazine-thiazolidone compound as well as preparation method and application thereof

The invention belongs to the field of medicinal chemistry, and relates to a triazine-thiazolidone compound as well as a preparation method and application thereof. The structural formula of the triazine-thiazolidinone compound is shown in the specification, wherein R1 is any one of alkyl, aryl or heteroaryl, and R2 is alkyl or aryl; the pharmaceutically acceptable salt is the acid salt of the compound, and the acid is any one of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, boric acid, methanesulfonic acid, p-toluenesulfonic acid, naphthalene sulfonic acid, benzenesulfonic acid, citric acid, lactic acid, pyruvic acid, tartaric acid, acetic acid, trifluoroacetic acid, maleic acid, succinic acid, mandelic acid, fumaric acid, salicylic acid or phenylacetic acid. The triazine-thiazolidone compound provided by the invention is novel in structure, has a very good inhibition effect on glucose transporter 1 (GLUT1), has an inhibition effect superior to that of a positive control compound BAY-87