Preparation method of 1-aryl-3-aryl sulfinyl bicyclo [1.1. 1] pentane

The invention discloses a preparation method of 1-aryl-3-aryl sulfinyl bicyclo [1.1. 1] pentane and a preparation method of the 1-aryl-3-aryl sulfinyl bicyclo [1.1. 1] pentane. The method comprises the following steps: reacting an aryl Grignard reagent with [1.1. 1] spirorane under the protection of inert gas, continuously reacting the obtained intermediate solution with an SO2 source, and after the reaction is finished, carrying out post-treatment to obtain the 1-aryl-3-aryl sulfinyl bicyclo [1.1. 1] pentane. According to the present invention, the efficient preparation of the 1-aryl-3-aryl sulfinyl bicyclo [1.1. 1] pentane can be achieved without adding any catalyst, and the method has advantages of low raw material cost, simple operation, mild condition, high reaction yield and the like, and has wide application value. 本发明公开了一种1-芳基-3-芳基亚磺酰基双环[1.1.1]戊烷的制备方法。在惰性气体保护下，将芳基格氏试剂与[1.1.1]螺桨烷反应，所得中间体溶液与SO2源继续反应，反应结束后经后处理得1-芳基-3-芳基亚磺酰基双环[1.1.1]戊烷。本发明无需添加任何催化剂，即可实现了1-芳基-3-芳基亚磺酰基双环[1.1.1]戊烷的高效制备，且原料成本低，具有操作简便、条件温和及反应收