Antiviral pharmaceutical composition as well as preparation process and application thereof

The invention discloses an antiviral pharmaceutical composition as well as a preparation process and application thereof. The antiviral pharmaceutical composition comprises the following components: (i) a compound I, or a monohydrate thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable long-chain ester thereof, and (ii) a biodegradable biocompatible polymer, wherein the component (i) exists in the composition in a crystal form and an amorphous form at the same time. According to the preparation method disclosed by the invention, the medicine composition with controllable medicine crystal form and content can be obtained, and the composition is high in medicine content, high in encapsulation efficiency, free of delayed release period, free of burst release, stable in in-vivo and in-vitro release and capable of continuously releasing for at least 28 days or more. 本发明公开了一种抗病毒药物组合物及其制备工艺与应用，所述抗病毒药物组合物包含以下组分：(i)化合物I，或其一水合物，或其药物学可接受的盐，或其药学上可接受的长链酯，和，(ii)生物可降解生物相容性高分子；其中，组分(i)在组合物