Preparation method and application of biological hydrogel for promoting bone defect repair

The invention discloses a preparation method and application of biological hydrogel for promoting bone defect repair. The preparation method comprises the following steps: dissolving SDF-1 and BMP-2 in PBS; the preparation method comprises the following steps: respectively dissolving 4-arm-PEG-NH2 and ODEX in a mixed solution of SDF-1 (Sodium Dodecyl Fluoride) and BMP-2 (Bone Morphogenetic The preparation method comprises the following steps: mixing a 4-arm-PEG-NH2 solution and an ODEX solution, and rotating; and standing to obtain the biological hydrogel. According to the technical scheme, the biological hydrogel carrying the cell factors is used for being placed into the bone defect, and the repairing and treating effects of the bone defect are improved; the material is mainly prepared by crosslinking 4-arm amino polyethylene glycol and oxidized dextran through a Schiff base reaction, and SDF-1 and BMP-2 are added in the material preparation process. The SDF-1 can induce homing of the bone marrow mesenchyma