Self-assembled in-situ nanogel as well as preparation method and application thereof

The invention discloses self-assembled in-situ nanogel as well as a preparation method and application thereof, and belongs to the field of pharmaceutical preparations. The active ingredients of the self-assembled in-situ nanogel disclosed by the invention are prepared from short-chain fatty acid and natural flavonoid compounds through chemical synthesis, are resistant to gastric acid, and form the nanogel in situ with a prepared gel matrix under the conditions that the pH is 6.5 and the temperature is 37 DEG C. The self-assembled in-situ nanogel solves the problem of drug degradation caused by strong acidity of gastric juice, not only solves the palatability problem of short-chain fatty acid and avoids mass absorption of the short-chain fatty acid in the stomach, but also endows the active ingredients with targeted adhesion at intestinal segment inflammation parts, and improves the acting time and acting efficiency of the active ingredients in the intestinal tract. 本发明公开了一种自组装原位纳米凝胶、制备方法及其应用，属于药物制剂领域；本发明公开的自