Preparation method of 3, 3-dichlorooxoindole and derivatives thereof

The invention discloses a preparation method of 3, 3-dichloro oxoindole and derivatives thereof, and belongs to the technical field of chemical synthesis, and the preparation method comprises the following steps: sequentially adding an indole compound, water and tetrahydrofuran into a pre-dried bottle, then adding chlorofluorosulfonyl, stirring at room temperature at 300-600 rpm, and after the reaction is finished, carrying out rotary evaporation and concentration on a reaction solution to obtain 3, 3-dichloro oxoindole; and performing column chromatography separation to obtain a target product. The invention discloses a preparation method of 3, 3-dichloro oxoindole and a derivative of the 3, 3-dichloro oxoindole. The method has the advantages of wide substrate application, cheap raw materials required by the reaction, mild reaction conditions and simple operation; the product can be used for further synthesis of skeleton molecules of various natural products, and has a good application prospect. 本发明公开了一种3，3-