Magnetized platelet drug delivery system and preparation method and application thereof

The invention discloses a magnetized platelet drug delivery system, a preparation method and application. The magnetized platelet drug delivery system comprises platelets, magnetic nanoparticles and drug nanoparticles, the magnetic nanoparticles and the drug nanoparticles are encapsulated in the cyt...

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Hauptverfasser: HUANG PENGYU, ZHANG YAN, WANG QIANGSONG, JIANG ZHENGPING
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a magnetized platelet drug delivery system, a preparation method and application. The magnetized platelet drug delivery system comprises platelets, magnetic nanoparticles and drug nanoparticles, the magnetic nanoparticles and the drug nanoparticles are encapsulated in the cytoplasm of the blood platelets. According to the magnetized platelet drug delivery system disclosed by the invention, the platelet is utilized to load the magnetic nanoparticles, so that the magnetized platelet drug delivery system has good magnetic migration capability, tumor targeted delivery of the magnetized platelet is realized under the tumor trend of the platelet and the guidance of an external magnetic field, and the concentration of the drug delivery system at a focus part is improved; the magnetized platelet-loaded microenvironment active oxygen and photo-thermal dual response drug nanoparticles avoid premature release of the drug, reduce toxic and side effects of the drug, improve drug administration safe