Ultrasonic-assisted preparation method of particle-size-precisely-controllable polydopamine nanoparticles

The invention discloses an ultrasonic-assisted preparation method of particle size precisely controllable polydopamine nanoparticles, which comprises the following steps: (1) adding absolute ethyl alcohol EtOH into deionized water to obtain a clear solution; and (2) adding dopamine hydrochloride powder into the settled solution, adjusting the pH value of the reaction solution through a 0.1 mol/L NaOH solution, enabling the concentration of the dopamine hydrochloride solution in the system to be 1-4 mg/mL, assisting ultrasonic action, reacting for 3-6 hours, centrifuging at a high speed, washing with water, and drying to obtain the polydopamine nanoparticles. According to the method, active oxygen is generated through the ultrasonic action to accelerate the polymerization speed of dopamine, the nucleation activation energy of polydopamine is reduced, the nucleation and growth processes of the polydopamine nanoparticles are effectively regulated and controlled, the polydopamine nanoparticles which are uniformly