Hollow mesoporous silicon dioxide loaded elemene nano-particles as well as preparation method and application of hollow mesoporous silicon dioxide loaded elemene nano-particles

The invention discloses hollow mesoporous silicon dioxide loaded elemene nanoparticles as well as a preparation method and application thereof. The preparation method comprises the following steps: synthesizing hollow mesoporous silica nanoparticles, dropwise adding a mixed solution of an elemene stock solution and absolute ethyl alcohol into a mixed solution of the hollow mesoporous silica nanoparticles and absolute ethyl alcohol at room temperature, stirring for 12 hours, and evaporating a solvent through a rotary evaporator to obtain the elemene nano-particles. The hollow mesoporous silica loaded elemene nano particles (HMSN-ELE) are obtained. The HMSN-ELE has relatively high drug delivery efficiency, can show a good slow release effect, can achieve the purpose of slowly and controllably releasing drugs when being applied to meta-acid tumor cells, and has a good killing effect on the tumor cells. 本发明公开了一种中空介孔二氧化硅负载榄香烯纳米颗粒、其制备方法及应用。本发明首先合成了中空介孔二氧化硅纳米颗粒，然后将榄香烯原液和无水乙醇的混合溶液，室温下滴加到以中空介孔二氧化硅纳米颗粒和无水乙醇的混合溶液中，搅拌12小