REPROGRAMMABLE IscB NUCLEASE AND USES THEREOF

Detailed herein are systems, methods, and compositions for targeting polynucleotides. In particular, engineered DNA targeting systems comprising an IscB polypeptide, a novel IscB nuclease, and a reprogrammable targeting nucleic acid component are provided as well as methods of use and applications....

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Bibliographische Detailangaben
Hauptverfasser:	ALTAY-TRAN HASAN, KANNAN SURESH, ZHANG FENG, DEMIRCIOGLU FARIBORZ EMRE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Detailed herein are systems, methods, and compositions for targeting polynucleotides. In particular, engineered DNA targeting systems comprising an IscB polypeptide, a novel IscB nuclease, and a reprogrammable targeting nucleic acid component are provided as well as methods of use and applications. 本文详述了用于靶向多核苷酸的系统、方法和组合物。特别地，提供了包含IscB多肽、新型IscB核酸酶和可重编程靶向核酸组分的工程化DNA靶向系统以及使用方法和应用。