Method for preparing acylated derivative of insulin or analogue thereof

The present disclosure provides a process for preparing an acylated derivative of insulin or an analog thereof, comprising the step of reacting insulin or an analog thereof with a compound of formula (I), as well as a compound of formula (I) and a process for preparing the same. The method disclosed by the invention is high in yield and stable in process, the production cost of the acylated derivative of the insulin or the analogue thereof can be greatly reduced, and large-scale commercial production can be realized. R-W-X-Y-Z is shown in the specification. 本公开提供了一种制备胰岛素或其类似物的酰化衍生物的方法，其包括使胰岛素或其类似物与式(I)的化合物反应的步骤，还提供了式(I)的化合物及其制备方法。本公开的方法不仅收率高，且工艺稳定，可大大降低胰岛素或其类似物的酰化衍生物的生产成本，且能够实现规模化的商业生产。R-W-X-Y-Z(I)。