Application of ANRIL in preparation of diagnostic kit for cardiovascular diseases related to chronic kidney diseases

The invention discloses application of ANRIL in preparation of a diagnostic kit for cardiovascular diseases related to chronic kidney diseases, belongs to the technical field of chronic kidney disease diagnosis, and finds that expression of ANRIL in plasma of patients with chronic kidney diseases is...

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Hauptverfasser: WANG RONG, LIU BING, SU HONG, LYU ZHIMEI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses application of ANRIL in preparation of a diagnostic kit for cardiovascular diseases related to chronic kidney diseases, belongs to the technical field of chronic kidney disease diagnosis, and finds that expression of ANRIL in plasma of patients with chronic kidney diseases is increased, the expression level of ANRIL is negatively correlated with renal functions and vascular endothelial function states, and the cardiovascular diseases related to chronic kidney diseases are negatively correlated with the vascular endothelial function states. The severity of the cardiovascular lesion of the CKD patient can be reflected to a certain extent. Meanwhile, the effect and mechanism of the compound participating in mediating endothelial cell dysfunction are further discussed and verified. The examination method is simple and easy to implement, causes little trauma to a subject, has better compliance to the subject, and lays a theoretical foundation for research and development of targeted drugs.