Preparation method of fluvoxamine

The invention relates to the field of chemical synthesis of medicines, in particular to a preparation method of fluvoxamine. The preparation method comprises the following steps: reacting an amine protecting group compound with 2-chloroethyl amine, and then adding 5-methoxy-1-(4-trifluoromethylphenyl) pentanone oxime to react to obtain a product; and reacting the resultant with hydrazine hydrate to obtain the fluvoxamine. According to the preparation method, a phosphorus-containing reagent is not used, so that the post-treatment cost is reduced, and the environmental pollution is reduced; the use of a sodium-hydrogen reagent is avoided, so that the safety risk of the reaction is reduced; the method has the advantages of simple operation, no substitution reaction between 2-chloroethylamine hydrochloride and fluvoxamine, increase of the reaction yield, obtaining of the intermediate with higher purity, and suitableness for process production amplification. 本发明涉及药物化学合成领域，具体为一种氟伏沙明的制备方法。该制备方法，将胺保护基化合物与2-氯乙基胺反应后，加入