Preparation method of composite hydrogel for enhancing bioactive glass osteogenesis based on black phosphorus

The preparation method comprises the following steps: adding bioactive glass and black phosphorus nanosheets into a photoinitiator solution, stirring to be uniform, adding methacrylic acid esterified gelatin, and stirring to obtain a mixed solution containing the methacrylic acid esterified gelatin; and adding polyethylene glycol diacrylate, stirring in a dark place until the mixture is uniform, and initiating a polymerization reaction under ultraviolet irradiation to obtain the composite hydrogel based on black phosphorus enhanced bioactive glass osteogenesis. According to the invention, through GelMA ultraviolet crosslinking, the black phosphorus nanosheet and the bioactive glass are wrapped, so that the black phosphorus nanosheet stably exists in vivo for a short time, and the degradation rate of black phosphorus is reduced; meanwhile, the bioactive glass provides a biomineralization environment for black phosphorus osteogenesis; the BP-mediated efficient photothermal effect can improve the local temperatu