Dendritic polypeptide nanogel loaded with hydrogen sulfide through electrostatic adsorption on montmorillonite and preparation method of dendritic polypeptide nanogel

Dendritic polypeptide nanogel loaded with hydrogen sulfide through electrostatic adsorption on montmorillonite and preparation method of dendritic polypeptide nanogel

The invention belongs to the technical field of biomacromolecules, and particularly relates to dendritic polypeptide nanogel loaded with hydrogen sulfide through electrostatic adsorption on montmorillonite and a preparation method of the dendritic polypeptide nanogel. According to the dendritic poly...

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Hauptverfasser: LI LIN, CHEN DONGFAN, CHEN JIALE, CAI XIAOJUN
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Sprache:chi ; eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator LI LIN
CHEN DONGFAN
CHEN JIALE
CAI XIAOJUN
description The invention belongs to the technical field of biomacromolecules, and particularly relates to dendritic polypeptide nanogel loaded with hydrogen sulfide through electrostatic adsorption on montmorillonite and a preparation method of the dendritic polypeptide nanogel. According to the dendritic polypeptide nanogel carrier, a third-generation lysine dendritic macromolecule with polyhedral oligomeric silsesquioxane (POSS) as a core is used as a branched unit POSS-Lys-G3, and blank nanogel PDNs is obtained through chemical crosslinking of a crosslinking agent 3, 3 '-dithiodipropionic acid di (N-hydroxysuccinimide) ester DSP. Diallyl trisulfide DATS molecules are loaded in the net structure of the dendritic polypeptide nanogel; the surface of the dendritic polypeptide nanogel is coated with the montmorillonite MM. The polypeptide has the beneficial effects that the polypeptide can specifically target damaged mucous membranes of large intestines, can respond to release H2S at a GSH level in a physiological state t
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Dendritic polypeptide nanogel loaded with hydrogen sulfide through electrostatic adsorption on montmorillonite and preparation method of dendritic polypeptide nanogel
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