Targeting Trop2 protein black phosphorus nanosheet as well as preparation method and application thereof

Targeting Trop2 protein black phosphorus nanosheet as well as preparation method and application thereof

The invention discloses a Trop2 protein-targeted black phosphorus nanosheet as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) preparing black phosphorus nanosheet dispersion liquid; (2) preparing a coupling agent mixed solution; (3) pr...

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Hauptverfasser: JIA LIZHOU, WANG TENGQI, ZHAO WEI, ZHANG NING, LIU YANG, FU YUHAO
Format: Patent
Sprache:chi ; eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator JIA LIZHOU
WANG TENGQI
ZHAO WEI
ZHANG NING
LIU YANG
FU YUHAO
description The invention discloses a Trop2 protein-targeted black phosphorus nanosheet as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) preparing black phosphorus nanosheet dispersion liquid; (2) preparing a coupling agent mixed solution; (3) preparing a black phosphorus nanosheet modified by a connecting agent; (4) oxidizing to prepare a Trop2IgG antibody solution with an aldehyde group; (5) preparing the black phosphorus nanosheet of the targeted Trop2 protein; the invention further discloses the Trop2 protein targeting black phosphorus nanosheet prepared by the method and application thereof. The preparation method of the Trop2 protein-targeted black phosphorus nanosheet is a brand-new preparation process, and is simple and convenient in flow, simple to operate and relatively high in yield; and the Trop2 protein targeting black phosphorus nanosheet prepared by the process not only has a specific inhibition effect on stomach cancer with high expression
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Targeting Trop2 protein black phosphorus nanosheet as well as preparation method and application thereof
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