Targeting Trop2 protein black phosphorus nanosheet as well as preparation method and application thereof

The invention discloses a Trop2 protein-targeted black phosphorus nanosheet as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) preparing black phosphorus nanosheet dispersion liquid; (2) preparing a coupling agent mixed solution; (3) preparing a black phosphorus nanosheet modified by a connecting agent; (4) oxidizing to prepare a Trop2IgG antibody solution with an aldehyde group; (5) preparing the black phosphorus nanosheet of the targeted Trop2 protein; the invention further discloses the Trop2 protein targeting black phosphorus nanosheet prepared by the method and application thereof. The preparation method of the Trop2 protein-targeted black phosphorus nanosheet is a brand-new preparation process, and is simple and convenient in flow, simple to operate and relatively high in yield; and the Trop2 protein targeting black phosphorus nanosheet prepared by the process not only has a specific inhibition effect on stomach cancer with high expression