Anti-B7H3 antibody and application thereof

The present application provides murine anti-B7H3 (CD276) antibodies, and chimeric forms and humanized forms thereof. The invention also provides a pharmaceutical composition containing the antibody, a vaccine, a nucleotide molecule encoding the antibody, an expression vector containing the nucleoti...

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Hauptverfasser:	ZHANG JIANQING, ZHANG KUNLIN, CHEN LITING, GAO XIN, DOU XIAOQIAN, YANG CUIMA, LIU YUJIE, WANG JINGJING, QIAN NILIANG, LI HONGJIE, XU GUILI, PENG CE, BAI GUIJUN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present application provides murine anti-B7H3 (CD276) antibodies, and chimeric forms and humanized forms thereof. The invention also provides a pharmaceutical composition containing the antibody, a vaccine, a nucleotide molecule encoding the antibody, an expression vector containing the nucleotide molecule, a host cell containing the expression vector and application of the antibody to treatment of B7H3 related diseases. 本申请提供了鼠源抗B7H3(CD276)抗体及其嵌合形式和人源化形式。本申请还提供了包含上述抗体的药物组合物、疫苗、编码上述抗体的核苷酸分子、包含所述核苷酸分子的表达载体、包含所述表达载体的宿主细胞以及利用上述抗体来治疗B7H3相关的疾病的用途。