Novel crystal form of BRD4 inhibitor compound, application and preparation method of BRD4 inhibitor compound

The invention relates to the field of crystal forms of drugs, in particular to a novel crystal form of N-ethyl-4-(5-(2-hydroxypropyl-2-yl)-3-(indoline-1-yl) thiophene-2-yl)-6-methyl-7-oxo-6, 7-dihydro-1H-pyrrolo [2, 3-c] pyridine-2-formamide and a preparation method of the novel crystal form of N-et...

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Hauptverfasser: WANG YING, CHEN HONG, ZHU HUI, YANG HAILONG, HUANG CUI, GU HUIKE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the field of crystal forms of drugs, in particular to a novel crystal form of N-ethyl-4-(5-(2-hydroxypropyl-2-yl)-3-(indoline-1-yl) thiophene-2-yl)-6-methyl-7-oxo-6, 7-dihydro-1H-pyrrolo [2, 3-c] pyridine-2-formamide and a preparation method of the novel crystal form of N-ethyl-4-(5-(2-hydroxypropyl-2-yl)-3-(indoline-1-yl) thiophene-2-yl)-6-methyl-7-oxo-6, 7-dihydro-1H-pyrrolo [2, 3-c] pyridine-2-formamide. The crystal form of the compound shown in the formula (I) has excellent physical stability and chemical stability and is more suitable for clinical use; meanwhile, preparation conditions of various crystal forms are mild, operation is easy, by controlling key parameters in the crystal form preparation process, the single crystal form can be obtained through the preparation method, process reproducibility is good, purity is high, industrial production conditions are controllable, and large-scale industrialization is facilitated. 本申请涉及药物晶型领域,具体涉及N-乙基-4-(5-(2-羟基丙基-2-基)-3-(吲哚啉-1-基)噻吩-2