Application of chlorpromazine in preparation of coronavirus inhibitor

The invention discloses an application of chlorpromazine in preparation of a coronavirus inhibitor. The invention provides application of chlorpromazine or pharmaceutically acceptable salt thereof, which is (a) or (b) or (c) or (d) as follows: (a) application in preparation of a coronavirus inhibito...

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Bibliographische Detailangaben
Hauptverfasser: MEI JIAJIA, MINEYAMA, WEI TAO, ZHAO JIANYUAN, REN LILI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses an application of chlorpromazine in preparation of a coronavirus inhibitor. The invention provides application of chlorpromazine or pharmaceutically acceptable salt thereof, which is (a) or (b) or (c) or (d) as follows: (a) application in preparation of a coronavirus inhibitor; (b) application in inhibition of coronavirus; (c) application in product preparation; the product is used for treating diseases caused by coronavirus infection. And (d) application in treating diseases caused by coronavirus infection. Experiments prove that chlorpromazine has good anti-SARS-CoV-2 activity and/or anti-HCoV-OC43, and has an important application prospect in the treatment of SARS-CoV-2 infection and/or HCoV-OC43 infection. 本发明公开了氯丙嗪在制备冠状病毒抑制剂中的应用。本发明提供了氯丙嗪或其在药学上可接受的盐的应用,为如下(a)或(b)或(c)或(d):(a)在制备冠状病毒抑制剂中的应用;(b)在抑制冠状病毒中的应用;(c)在制备产品中的应用;所述产品的用途为治疗冠状病毒感染引起的疾病;(d)在治疗冠状病毒感染引起的疾病中的应用。本发明通过实验证明氯丙嗪具有良好的抗SARS-CoV-2活性和/或抗HCoV-OC43,具有重要的治疗SARS-CoV-2感染和/或HCoV-OC43感染的应用前景。