7-hydroxy-butylphthalide nano-emulsion preparation as well as preparation method and application thereof
The invention provides a 7-hydroxy-butylphthalide nano-emulsion preparation as well as a preparation method and application thereof. The invention develops a 7-hydroxy-butylphthalide nano-emulsion preparation containing a phospholipid PEG derivative. The molecular action mechanism of 7-hydroxy-butyl...
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| creator | SUN CHAO YAN BAIYI SHEN WENBIN GAO FURAN XIE YING SUN LIYU ZHANG NALING CHEN SONGYUE WU MI CHEN KUN SONG XINYI ZHANG XUEXIA LU XINHUA WANG MENGJIE KANG SHUAI ZHU JINGTONG |
| description | The invention provides a 7-hydroxy-butylphthalide nano-emulsion preparation as well as a preparation method and application thereof. The invention develops a 7-hydroxy-butylphthalide nano-emulsion preparation containing a phospholipid PEG derivative. The molecular action mechanism of 7-hydroxy-butylphthalide, phospholipid and the phospholipid PEG derivative in the preparation is disclosed through multi-scale calculation simulation; the specification of the preparation is determined through prescription and process optimization; the effectiveness of the preparation for treating cerebral apoplexy is verified through animal in-vivo pharmacodynamic evaluation, and a reliable dosage form is provided for meeting clinical medication. The problems that 7-hydroxy-butylphthalide is poor in solubility and difficult to prepare medicines are solved. Quality investigation shows that the encapsulation efficiency, the particle size, the Zeta potential and the like of the 7-hydroxy-butylphthalide nano-emulsion meet the qualit |
| format | Patent |
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The invention develops a 7-hydroxy-butylphthalide nano-emulsion preparation containing a phospholipid PEG derivative. The molecular action mechanism of 7-hydroxy-butylphthalide, phospholipid and the phospholipid PEG derivative in the preparation is disclosed through multi-scale calculation simulation; the specification of the preparation is determined through prescription and process optimization; the effectiveness of the preparation for treating cerebral apoplexy is verified through animal in-vivo pharmacodynamic evaluation, and a reliable dosage form is provided for meeting clinical medication. The problems that 7-hydroxy-butylphthalide is poor in solubility and difficult to prepare medicines are solved. 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The invention develops a 7-hydroxy-butylphthalide nano-emulsion preparation containing a phospholipid PEG derivative. The molecular action mechanism of 7-hydroxy-butylphthalide, phospholipid and the phospholipid PEG derivative in the preparation is disclosed through multi-scale calculation simulation; the specification of the preparation is determined through prescription and process optimization; the effectiveness of the preparation for treating cerebral apoplexy is verified through animal in-vivo pharmacodynamic evaluation, and a reliable dosage form is provided for meeting clinical medication. The problems that 7-hydroxy-butylphthalide is poor in solubility and difficult to prepare medicines are solved. Quality investigation shows that the encapsulation efficiency, the particle size, the Zeta potential and the like of the 7-hydroxy-butylphthalide nano-emulsion meet the qualit</abstract><oa>free_for_read</oa></addata></record> |
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| title | 7-hydroxy-butylphthalide nano-emulsion preparation as well as preparation method and application thereof |
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