7-hydroxy-butylphthalide nano-emulsion preparation as well as preparation method and application thereof

The invention provides a 7-hydroxy-butylphthalide nano-emulsion preparation as well as a preparation method and application thereof. The invention develops a 7-hydroxy-butylphthalide nano-emulsion preparation containing a phospholipid PEG derivative. The molecular action mechanism of 7-hydroxy-butylphthalide, phospholipid and the phospholipid PEG derivative in the preparation is disclosed through multi-scale calculation simulation; the specification of the preparation is determined through prescription and process optimization; the effectiveness of the preparation for treating cerebral apoplexy is verified through animal in-vivo pharmacodynamic evaluation, and a reliable dosage form is provided for meeting clinical medication. The problems that 7-hydroxy-butylphthalide is poor in solubility and difficult to prepare medicines are solved. Quality investigation shows that the encapsulation efficiency, the particle size, the Zeta potential and the like of the 7-hydroxy-butylphthalide nano-emulsion meet the qualit