High-stability furosemide injection as well as preparation method and application thereof
The invention relates to a high-stability furosemide injection as well as a preparation method and application thereof. The furosemide injection consists of furosemide, an osmotic pressure regulator, sodium hydroxide, a pH regulator and water for injection, the preparation method comprises the follo...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention relates to a high-stability furosemide injection as well as a preparation method and application thereof. The furosemide injection consists of furosemide, an osmotic pressure regulator, sodium hydroxide, a pH regulator and water for injection, the preparation method comprises the following specific preparation steps: step S1: preparation process; the preparation method comprises the following steps: adding water for injection into a liquid preparation tank, heating to 60-80 DEG C, sequentially adding furosemide and sodium hydroxide, stirring until furosemide and sodium hydroxide are completely dissolved, then adding the water for injection and the osmotic pressure regulator again, continuously filling nitrogen in the preparation process, cooling to 20-30 DEG C, regulating the pH value to 9.0-9.3, and supplementing the water for injection to a constant volume; step S2, a filling process; and S3, a sterilization process. Compared with the prior art, the furosemide injection has the advantages that |
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