COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING AUTOIMMUNE DISORDERS

The present invention relates generally to compositions comprising gel-based inulin formulations associated (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, blended) with one or more therapeutic agents (e.g., immunomodulators, immunosuppressants, allergens) and related methods for treating autoimmune disorders (e.g., colitis) (e.g., allergies, e.g., food allergies). Also provided herein are compositions and methods for modulating an immune response associated with an autoimmune disorder (e.g., allergy) and/or inducing immune tolerance or desensitization to an autoimmune disorder (e.g., allergy, e.g., food allergy). 本发明一般地涉及包含与一种或多种治疗剂(例如，免疫调节剂、免疫抑制剂、过敏原)缔合(例如，络合、共轭、封装、吸收、吸附、掺混)的基于凝胶的菊粉制剂的组合物以及用于治疗自身免疫性病症(例如结肠炎)(例如过敏，例如食物过敏)的相关方法。本文还提供了用于调节与自身免疫性病症(例如，过敏)相关的免疫应答和/或诱导对自身免疫性病症(例如过敏，例如食物过敏)的免疫耐受或脱敏的组合物和方法。