Application of BACE1 restriction enzyme cutting site on GABAA receptor beta subunit as Alzheimer disease diagnosis or treatment target site
The invention discloses an application of a BACE1 restriction enzyme cutting site on a GABAA receptor beta subunit as a target site for diagnosing or treating Alzheimer's disease. The GABAA receptor beta subunit is at least one of a GABAA receptor beta 1 subunit, a GABAA receptor beta 2 subunit...
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| creator | YANG XIAOLI WU ZUJUN BI DANLEI BAO HONG SHEN YONG GAO FENG |
| description | The invention discloses an application of a BACE1 restriction enzyme cutting site on a GABAA receptor beta subunit as a target site for diagnosing or treating Alzheimer's disease. The GABAA receptor beta subunit is at least one of a GABAA receptor beta 1 subunit, a GABAA receptor beta 2 subunit and a GABAA receptor beta 3 subunit. The BACE1 restriction enzyme cutting sites on the GABAA receptor beta 1 subunit and the GABAA receptor beta 3 subunit are L235/S236, and the BACE1 restriction enzyme cutting site on the GABAA receptor beta 2 subunit is L234/S235. The AD detection and treatment method developed on the basis of the BACE1 enzyme digestion GABAA receptor beta1-3 subunit has important conversion application prospects and significance.
本发明公开了一种GABAA受体β亚基上BACE1酶切位点作为阿尔茨海默病诊断或治疗靶位点的应用，所述GABAA受体β亚基为GABAA受体β1亚基、GABAA受体β2亚基、GABAA受体β3亚基中的至少一种；所述GABAA受体β1亚基、GABAA受体β3亚基上BACE1酶切位点为L235/S236，GABAA受体β2亚基上BACE1酶切位点为L234/S235。本发明基于BACE1酶切GABAA受体β1-3亚基开发的检测及治疗AD方法，具有重要的转化应用前景及意义。 |
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本发明公开了一种GABAA受体β亚基上BACE1酶切位点作为阿尔茨海默病诊断或治疗靶位点的应用，所述GABAA受体β亚基为GABAA受体β1亚基、GABAA受体β2亚基、GABAA受体β3亚基中的至少一种；所述GABAA受体β1亚基、GABAA受体β3亚基上BACE1酶切位点为L235/S236，GABAA受体β2亚基上BACE1酶切位点为L234/S235。本发明基于BACE1酶切GABAA受体β1-3亚基开发的检测及治疗AD方法，具有重要的转化应用前景及意义。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230801&DB=EPODOC&CC=CN&NR=116519943A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230801&DB=EPODOC&CC=CN&NR=116519943A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YANG XIAOLI</creatorcontrib><creatorcontrib>WU ZUJUN</creatorcontrib><creatorcontrib>BI DANLEI</creatorcontrib><creatorcontrib>BAO HONG</creatorcontrib><creatorcontrib>SHEN YONG</creatorcontrib><creatorcontrib>GAO FENG</creatorcontrib><title>Application of BACE1 restriction enzyme cutting site on GABAA receptor beta subunit as Alzheimer disease diagnosis or treatment target site</title><description>The invention discloses an application of a BACE1 restriction enzyme cutting site on a GABAA receptor beta subunit as a target site for diagnosing or treating Alzheimer's disease. The GABAA receptor beta subunit is at least one of a GABAA receptor beta 1 subunit, a GABAA receptor beta 2 subunit and a GABAA receptor beta 3 subunit. The BACE1 restriction enzyme cutting sites on the GABAA receptor beta 1 subunit and the GABAA receptor beta 3 subunit are L235/S236, and the BACE1 restriction enzyme cutting site on the GABAA receptor beta 2 subunit is L234/S235. The AD detection and treatment method developed on the basis of the BACE1 enzyme digestion GABAA receptor beta1-3 subunit has important conversion application prospects and significance.
本发明公开了一种GABAA受体β亚基上BACE1酶切位点作为阿尔茨海默病诊断或治疗靶位点的应用，所述GABAA受体β亚基为GABAA受体β1亚基、GABAA受体β2亚基、GABAA受体β3亚基中的至少一种；所述GABAA受体β1亚基、GABAA受体β3亚基上BACE1酶切位点为L235/S236，GABAA受体β2亚基上BACE1酶切位点为L234/S235。本发明基于BACE1酶切GABAA受体β1-3亚基开发的检测及治疗AD方法，具有重要的转化应用前景及意义。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjD0KwkAQRtNYiHqH8QAWwR-w3AR_Kit7GdfPOJDsLjuTQq_gpQ3iAawePB5vXLxdSq14NomB4p0qV-9KylDL4r8S4fXsQL43k9CQioEGfXCVc0PokSxmusKYtL_2QYxYybWvB6RDppsoWDGQmxBVlIbcMtg6BCPj3MC-22kxunOrmP04Keb73bk-LpDiBZrYI8Au9aksN-tyu10t3fKf5gMkxEye</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>YANG XIAOLI</creator><creator>WU ZUJUN</creator><creator>BI DANLEI</creator><creator>BAO HONG</creator><creator>SHEN YONG</creator><creator>GAO FENG</creator><scope>EVB</scope></search><sort><creationdate>20230801</creationdate><title>Application of BACE1 restriction enzyme cutting site on GABAA receptor beta subunit as Alzheimer disease diagnosis or treatment target site</title><author>YANG XIAOLI ; WU ZUJUN ; BI DANLEI ; BAO HONG ; SHEN YONG ; GAO FENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116519943A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>YANG XIAOLI</creatorcontrib><creatorcontrib>WU ZUJUN</creatorcontrib><creatorcontrib>BI DANLEI</creatorcontrib><creatorcontrib>BAO HONG</creatorcontrib><creatorcontrib>SHEN YONG</creatorcontrib><creatorcontrib>GAO FENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YANG XIAOLI</au><au>WU ZUJUN</au><au>BI DANLEI</au><au>BAO HONG</au><au>SHEN YONG</au><au>GAO FENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Application of BACE1 restriction enzyme cutting site on GABAA receptor beta subunit as Alzheimer disease diagnosis or treatment target site</title><date>2023-08-01</date><risdate>2023</risdate><abstract>The invention discloses an application of a BACE1 restriction enzyme cutting site on a GABAA receptor beta subunit as a target site for diagnosing or treating Alzheimer's disease. The GABAA receptor beta subunit is at least one of a GABAA receptor beta 1 subunit, a GABAA receptor beta 2 subunit and a GABAA receptor beta 3 subunit. The BACE1 restriction enzyme cutting sites on the GABAA receptor beta 1 subunit and the GABAA receptor beta 3 subunit are L235/S236, and the BACE1 restriction enzyme cutting site on the GABAA receptor beta 2 subunit is L234/S235. The AD detection and treatment method developed on the basis of the BACE1 enzyme digestion GABAA receptor beta1-3 subunit has important conversion application prospects and significance.
本发明公开了一种GABAA受体β亚基上BACE1酶切位点作为阿尔茨海默病诊断或治疗靶位点的应用，所述GABAA受体β亚基为GABAA受体β1亚基、GABAA受体β2亚基、GABAA受体β3亚基中的至少一种；所述GABAA受体β1亚基、GABAA受体β3亚基上BACE1酶切位点为L235/S236，GABAA受体β2亚基上BACE1酶切位点为L234/S235。本发明基于BACE1酶切GABAA受体β1-3亚基开发的检测及治疗AD方法，具有重要的转化应用前景及意义。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | Application of BACE1 restriction enzyme cutting site on GABAA receptor beta subunit as Alzheimer disease diagnosis or treatment target site |
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