Application of BACE1 restriction enzyme cutting site on GABAA receptor beta subunit as Alzheimer disease diagnosis or treatment target site

Application of BACE1 restriction enzyme cutting site on GABAA receptor beta subunit as Alzheimer disease diagnosis or treatment target site

The invention discloses an application of a BACE1 restriction enzyme cutting site on a GABAA receptor beta subunit as a target site for diagnosing or treating Alzheimer's disease. The GABAA receptor beta subunit is at least one of a GABAA receptor beta 1 subunit, a GABAA receptor beta 2 subunit...

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Bibliographische Detailangaben
Hauptverfasser: YANG XIAOLI, WU ZUJUN, BI DANLEI, BAO HONG, SHEN YONG, GAO FENG
Format: Patent
Sprache:chi ; eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
TESTING
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention discloses an application of a BACE1 restriction enzyme cutting site on a GABAA receptor beta subunit as a target site for diagnosing or treating Alzheimer's disease. The GABAA receptor beta subunit is at least one of a GABAA receptor beta 1 subunit, a GABAA receptor beta 2 subunit and a GABAA receptor beta 3 subunit. The BACE1 restriction enzyme cutting sites on the GABAA receptor beta 1 subunit and the GABAA receptor beta 3 subunit are L235/S236, and the BACE1 restriction enzyme cutting site on the GABAA receptor beta 2 subunit is L234/S235. The AD detection and treatment method developed on the basis of the BACE1 enzyme digestion GABAA receptor beta1-3 subunit has important conversion application prospects and significance. 本发明公开了一种GABAA受体β亚基上BACE1酶切位点作为阿尔茨海默病诊断或治疗靶位点的应用，所述GABAA受体β亚基为GABAA受体β1亚基、GABAA受体β2亚基、GABAA受体β3亚基中的至少一种；所述GABAA受体β1亚基、GABAA受体β3亚基上BACE1酶切位点为L235/S236，GABAA受体β2亚基上BACE1酶切位点为L234/S235。本发明基于BACE1酶切GABAA受体β1-3亚基开发的检测及治疗AD方法，具有重要的转化应用前景及意义。