Engineered yeast for producing beta-elemene and application thereof

The invention discloses engineered yeast for producing beta-elemene and application of the engineered yeast, and relates to the field of microbial pharmacy. The beta-elemene can be efficiently produced, the shake flask fermentation yield of the beta-elemene is close to 300mg/L, and the fermentation yield of a 1L fermentation tank can reach 1.8 g/L, which is the highest yield reported at present. The beta-elemene is efficiently generated by using the pichia pastoris, and the method has the characteristics of short period, environmental protection and resource conservation. The high-yield beta-elemene pichia pastoris engineering bacterium disclosed by the invention has a wide application prospect. 本发明公开了一种生产β-榄香烯的酵母工程菌及其应用，涉及微生物制药领域。本发明可以高效生产β-榄香烯，其摇瓶发酵产量接近300mg/L，lL发酵罐发酵产量最高可达1.8g/L，为目前报道最高产量。本发明利用毕赤酵母高效生成β-榄香烯，具有周期短，环保和节约资源的特点。本发明高产β-榄香烯的毕赤酵母工程菌具有广阔的应用前景。