Preparation method of modified cyclodextrin composite hydrogel for cartilage repair
The invention discloses a preparation method of modified cyclodextrin composite hydrogel for cartilage repair, which comprises the following steps: uniformly mixing a beta-cyclodextrin aqueous solution and sodium periodate, heating to react, separating out a reaction product by using ethanol, and ca...
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| creator | JIN YUFENG WANG YIFAN ZHANG MINGHAO HUO SIYONG ZHOU LIUQI ZENG QIAN HANG FEI |
| description | The invention discloses a preparation method of modified cyclodextrin composite hydrogel for cartilage repair, which comprises the following steps: uniformly mixing a beta-cyclodextrin aqueous solution and sodium periodate, heating to react, separating out a reaction product by using ethanol, and carrying out suction filtration and washing to obtain modified beta-cyclodextrin; dissolving polyethylene glycol diacrylate and chitosan, adding an initiator and a cross-linking agent, then adding the modified beta-cyclodextrin to obtain hydrogel slurry, centrifuging to remove bubbles, putting into a mold, initiating polymerization reaction under ultraviolet irradiation, and soaking in an ionic solution to obtain the modified cyclodextrin composite hydrogel for cartilage repair. The composite hydrogel provided by the invention has good mechanical properties, can support cell growth and chondrogenic differentiation, has good biodegradability, biocompatibility and extremely low cytotoxicity, has good photoresponsivenes |
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| subjects | AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-UP WORKING-UP |
| title | Preparation method of modified cyclodextrin composite hydrogel for cartilage repair |
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