Preparation method of modified cyclodextrin composite hydrogel for cartilage repair

The invention discloses a preparation method of modified cyclodextrin composite hydrogel for cartilage repair, which comprises the following steps: uniformly mixing a beta-cyclodextrin aqueous solution and sodium periodate, heating to react, separating out a reaction product by using ethanol, and ca...

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Bibliographische Detailangaben
Hauptverfasser: JIN YUFENG, WANG YIFAN, ZHANG MINGHAO, HUO SIYONG, ZHOU LIUQI, ZENG QIAN, HANG FEI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a preparation method of modified cyclodextrin composite hydrogel for cartilage repair, which comprises the following steps: uniformly mixing a beta-cyclodextrin aqueous solution and sodium periodate, heating to react, separating out a reaction product by using ethanol, and carrying out suction filtration and washing to obtain modified beta-cyclodextrin; dissolving polyethylene glycol diacrylate and chitosan, adding an initiator and a cross-linking agent, then adding the modified beta-cyclodextrin to obtain hydrogel slurry, centrifuging to remove bubbles, putting into a mold, initiating polymerization reaction under ultraviolet irradiation, and soaking in an ionic solution to obtain the modified cyclodextrin composite hydrogel for cartilage repair. The composite hydrogel provided by the invention has good mechanical properties, can support cell growth and chondrogenic differentiation, has good biodegradability, biocompatibility and extremely low cytotoxicity, has good photoresponsivenes