Heterocyclic compound with AKT kinase inhibition activity and preparation method and medical application thereof

The invention relates to a heterocyclic compound with AKT kinase inhibition activity and a preparation method and medical application thereof. Specifically, the invention relates to a compound shown in a general formula (I), a preparation method of the compound, a pharmaceutical composition containi...

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Hauptverfasser: CHEN ZHENHUA, CAI XUCAN, LIU GUOBIAO, SHANG FEI, YAN XU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a heterocyclic compound with AKT kinase inhibition activity and a preparation method and medical application thereof. Specifically, the invention relates to a compound shown in a general formula (I), a preparation method of the compound, a pharmaceutical composition containing the compound, and application of the compound as an AKT kinase inhibitor in drugs for preventing and/or treating abnormal cell growth such as cancers. The definition of each group in general formula (I) is the same as the definition in the description. 本发明涉及具有AKT激酶抑制活性的杂环化合物及其制备方法和医药用途。具体地,本发明涉及通式(I)所示的化合物,其制备方法,含有其的药物组合物,以及其作为AKT激酶抑制剂在预防和/或治疗异常细胞生长如癌症的药物中的用途。通式(I)中的各基团的定义与说明书中的定义相同。