Anti-PDL1/IGF1R bispecific antibody as well as preparation method and application thereof

The invention belongs to the technical field of tumor treatment and biology, and discloses an anti-PDL1/IGF1R bispecific antibody and a preparation method and application thereof, and the anti-PDL1/IGF1R bispecific antibody comprises a first antigen binding functional domain specifically bound with...

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Hauptverfasser: ZHU ZHENPING, GU CHANGLING, HUANG HAOMIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of tumor treatment and biology, and discloses an anti-PDL1/IGF1R bispecific antibody and a preparation method and application thereof, and the anti-PDL1/IGF1R bispecific antibody comprises a first antigen binding functional domain specifically bound with PDL1 and a second antigen binding functional domain specifically bound with IGF1R. The bispecific antibody can well maintain the activity of anti-PDL1 and anti-IGF1R monoclonal antibodies at the same time, can inhibit proliferation of tumor cells expressing IGF1R, can block a PD1/PDL1 signal channel, and has a unique effect of mediating a cell surface receptor to endocytosis to lysosome degradation; the bispecific antibody disclosed by the invention has the tumor cell killing activity obviously superior to that of a monoclonal antibody, and has the potential of preparing medicines for preventing and treating tumors. 本发明属于肿瘤治疗和生物技术领域,公开了一种抗PDL1/IGF1R双特异性抗体、其制备方法及用途,所述的抗PDL1/IGF1R双特异性抗体,包括:特异性结合PDL1的第一抗原结合功能域,和特异性结合I