Multi-ring cap dependent endonuclease inhibitors for treatment or prevention of influenza

The present invention provides compounds of formula (I) and pharmaceutical compositions comprising one or more of the compounds, as well as methods of treating or preventing influenza using the compounds. The compounds are cap dependent endonuclease inhibitors. 本发明提供了式(I)的化合物和包含一种或多种所述化合物的药物组合物,以及使用...

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Hauptverfasser: SOO HWAILI, SCHULTHOFF VINCENT W, MORIELLO GREGORI J, GUO LINFENG, PLOTKIN MICHAEL A, LO MICHAEL MANU, KIM RONALD M, DEJESUS RANA K, EMBREE MATTHEW W, MCCAULEY JOHN A, FELLS JULIAN, ZHANG YONGLIAN, DELLA RUIZ MARCOS, CHOUBANIAN HARSHAD R, ZHAO KAKE, CRAWLEY BRUCE M, BENNETT FRANK
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention provides compounds of formula (I) and pharmaceutical compositions comprising one or more of the compounds, as well as methods of treating or preventing influenza using the compounds. The compounds are cap dependent endonuclease inhibitors. 本发明提供了式(I)的化合物和包含一种或多种所述化合物的药物组合物,以及使用所述化合物治疗或预防流感的方法。所述化合物是帽依赖性核酸内切酶抑制剂。