Fermentation production method for improving yield of fucosyllactose of Escherichia coli

The invention belongs to the technical field of microbial fermentation, and particularly relates to a fermentation production method for increasing the yield of fucosyllactose of Escherichia coli. According to the method disclosed by the invention, the strains are inoculated again and the lactose is supplemented in the decline stage of the growth of the escherichia coli flora, so that the fermentation yield of the 2 '-fucosyllactose and the 3-fucosyllactose is increased, and the impurity types of the product are reduced. The invention provides a new production process for improving the industrial fermentation yield of 2 '-fucosyllactose or 3-fucosyllactose and meeting the market demand. 本发明属于微生物发酵技术领域，具体涉及一种提高大肠埃希氏菌岩藻糖基乳糖产量的发酵生产方法。本发明通过在大肠埃希氏菌菌群生长的衰退期再次接种菌种和补加乳糖，提高了2'-岩藻糖基乳糖和3-岩藻糖基乳糖的发酵产量，且减少了产品的杂质种类。为提高2'-岩藻糖基乳糖或3-岩藻糖基乳糖的工业发酵产量、满足市场需求提供了新的生产工艺。