Histone methyltransferase inhibitor and preparation method thereof

The invention belongs to the technical field of histone methyltransferase. The invention provides a histone methyltransferase inhibitor and a preparation method thereof, the structural formula of the histone methyltransferase inhibitor is as follows: the invention provides the histone methyltransferase inhibitor with a new skeleton, and the half inhibitory concentration (IC50) of the histone methyltransferase inhibitor to histone methyltransferase can reach 127nM. 本发明属于组蛋白甲基转移酶技术领域。本发明提供了一种组蛋白甲基转移酶抑制剂及其制备方法，所述组蛋白甲基转移酶抑制剂的结构式为本发明提供了一种具有新骨架的组蛋白甲基转移酶抑制剂，其对组蛋白甲基转移酶的半抑制浓度(IC50)可达127nM。