Preparation method and application of composite hydrogel for promoting bone defect repair

The invention discloses a preparation method and application of composite hydrogel for promoting bone defect repair. The preparation method comprises the following steps: dissolving IGF-1 (Insulin-like Growth Factor-1) in PBS (Phosphate Buffer Solution); the preparation method comprises the following steps: respectively dissolving 4-arm-PEG-NH2 and ODEX in an IGF-1 solution; the preparation method comprises the following steps: mixing a 4-arm-PEG-NH2 solution and an ODEX solution, and rotating; and standing to obtain the composite hydrogel. According to the technical scheme, the composite hydrogel carrying the cell factors is used for being placed into the bone defect, and the repairing and treating effects of the bone defect are improved; the material is mainly prepared by cross-linking four-arm amino polyethylene glycol and oxidized dextran through a Schiff base reaction, and insulin-like growth factor-1 is loaded in the material preparation process. The IGF-1 has the effect of strongly promoting proliferat