Synthesis method of deuterium or tritium labeled docetaxel

The invention discloses a preparation method of deuterium or tritium labeled docetaxel, which comprises the following steps: (1) under the action of organic alkali, carrying out esterification reaction on deuterium or tritiated tert-butyl alcohol and p-nitrophenyl chloroformate to obtain deuterium or tritiated (4-nitrophenyl) tert-butyl carbonate; and (2) carrying out amidation reaction on the deuterium or tritiated (4-nitrophenyl) tert-butyl carbonate obtained in the step (1) and a compound IM-1, and after the reaction is completed, carrying out post-treatment to obtain docetaxel, the synthesis method has the advantages of convenient intermediate synthesis, stable chemical properties, high utilization rate of the deuterated reagent and high product yield. 本发明公开了一种氘或氚标记的多西他赛的制备方法，包括以下步骤：(1)在有机碱的作用下，氘或氚代叔丁醇和对硝基苯基氯甲酸酯进行酯化反应，得到氘或氚代(4-硝基苯基)碳酸叔丁酯；(2)步骤(1)得到的氘或氚代(4-硝基苯基)碳酸叔丁酯与化合物IM-1进行酰胺化反应，反应完成后经过后处理得到所述的多西他赛；该合成方法中间体合成方便，化学性质稳定，并且氘代试剂的利用率和产物收率高。