Metal nanoparticle hybrid polymer vesicle as well as preparation method and application thereof

The invention discloses a metal nanoparticle hybrid polymer vesicle as well as a preparation method and application thereof. The method comprises the following steps: adding a segmented copolymer solution into a metal salt aqueous solution through an injector pump, namely preparing to obtain a prepa...

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Hauptverfasser: LUO WANRU, YU QIANQIAN, WANG LINGE, TAN FANGRONG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a metal nanoparticle hybrid polymer vesicle as well as a preparation method and application thereof. The method comprises the following steps: adding a segmented copolymer solution into a metal salt aqueous solution through an injector pump, namely preparing to obtain a prepared hybrid vesicle through a solvent exchange method; dialyzing the prepared hybrid vesicles, and removing unloaded metal ions; and adding an oxidizing agent or a reducing agent into the prepared hybridized vesicles after dialysis to obtain the metal nanoparticle hybridized polymer vesicles. The operation is simple, the repeatability is high, the prepared hybrid polymer vesicle can be used as a nano motor during drug delivery, the tumor infiltration capacity can be improved under the action of pushing force, and after degradation in cells, the metal nanoparticles can also be used as nano enzyme to generate a treatment effect, so that the drug delivery efficiency is improved. The hybrid polymer vesicle has excellent