GDF15 targeting fully humanized antibody and application thereof

The invention provides a fully humanized antibody targeting GDF15 and application thereof, the fully humanized antibody targeting GDF15 comprises a heavy chain variable region and a light chain variable region, the heavy chain variable region comprises HCDR1 as shown in SEQ ID NO.1, HCDR2 as shown i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: TAN TAOCHAO, JIA XIANGYIN, WEI QIAOE, XIE MENG, ZHANG QIANQIAN, LIU JIANWEI
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention provides a fully humanized antibody targeting GDF15 and application thereof, the fully humanized antibody targeting GDF15 comprises a heavy chain variable region and a light chain variable region, the heavy chain variable region comprises HCDR1 as shown in SEQ ID NO.1, HCDR2 as shown in SEQ ID NO.2 and HCDR3 as shown in SEQ ID NO.3, the light chain variable region comprises LCDR1 and LCDR2 as shown in SEQ ID NO.4 and LCDR3 as shown in SEQ ID NO.5, and the amino acid sequence of the LCDR2 is INN. According to the present invention, the GDF15 targeting completely humanized antibody specifically binds to GDF15 with high affinity, can block the binding of GDF15 and its receptor GPRAL, and has characteristics of low immunogenicity and good application potential in the development of antibody drugs compared with the heterologous antibody. 本发明提供一种靶向GDF15的全人源抗体及其应用,所述靶向GDF15的全人源抗体包括重链可变区和轻链可变区,所述重链可变区包括SEQ ID NO.1所示的HCDR1,SEQ ID NO.2所示的HCDR2,SEQ ID NO.3所示的HCDR3,所述轻链可变区包括SEQ ID NO.4所示的LCDR1,LCDR2,SEQ ID