Pyrimidine-2, 4-diamine derivative as well as preparation method and application thereof

The invention provides a pyrimidine-2, 4-diamine derivative as well as a preparation method and application thereof, and particularly, the pyrimidine-2, 4-diamine derivative is shown as a formula I. The invention further provides a preparation method and application of the pyrimidine-2, 4-diamine derivative. The pyrimidine-2, 4-diamine derivative provided by the invention has very high inhibitory activity on a drug-resistant tumor cell strain, especially on a drug-resistant tumor cell strain of an EGFR (epidermal growth factor receptor) small-molecule inhibitor, and further, the pyrimidine-2, 4-diamine derivative provided by the invention can be used for treating advanced tumors, especially advanced lung cancer, and can be used for preventing and treating tumor tumors. Especially small cell lung cancer and non-small cell lung cancer resistant to targeted drug treatment. 本发明提供一种嘧啶-2,4-二胺衍生物及其制备方法和用途，具体地，所述的嘧啶-2,4-二胺衍生物如式一所示。本发明提供的嘧啶-2,4-二胺衍生物对耐药的肿瘤细胞株具有很高的抑制活性，尤其对EGFR小分子抑制剂耐药的肿瘤细胞株，进一步地，本发明提供的嘧啶-2,4-二胺衍生物可以用于治