Nonmetal catalysis and column chromatography-free synthesis method of pyridyl substituted asymmetric urea

The invention discloses a non-metal catalysis and column chromatography-free synthesis method of pyridyl-substituted asymmetric urea, which is a novel non-metal catalysis and column chromatography-free tandem reaction one-pot synthesis method, is used for synthesizing 2-pyridyl-substituted asymmetric urea, aims at a series of aromatic amines and aliphatic amines, has the yield close to equivalent conversion, and has the advantages of high yield and high yield. The reaction efficiency is not affected by electron donating and electron withdrawing groups on cyclic secondary amine containing sp2C, sp3C, O, S and N atoms, the compatibility to ring systems with different tensions and chiral groups substituted on the rings is good, and amplification is easy. A simple, efficient, sustainable and green synthesis scheme is provided, and asymmetric urea is constructed with a very small amount of waste and very high atom economy. 本发明公开了吡啶基取代不对称脲的非金属催化、免柱层析合成方法，是一种新颖非金属催化、免柱层析的串联反应一锅合成方法，用于合成2-吡啶基取代不对称脲，针对一系列芳香胺和脂肪胺，收率都接近