Application of broussonetia papyrifera polysaccharide in preparation of medicine for preventing or treating liver injury

The invention discloses a novel application of broussonetia papyrifera polysaccharide, namely an application of the broussonetia papyrifera polysaccharide in preparation of a medicine for preventing or treating liver injury. The inventor establishes a mouse liver injury model through acetaminophen,...

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Hauptverfasser: SI HONGBIN, XU BAICHANG, CHEN XIAOGANG, LIAO MAOLIANG, WU ENYUN, LIU AILING, MENG XIAOBIN, FANG ZIYI, MENG JINYAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a novel application of broussonetia papyrifera polysaccharide, namely an application of the broussonetia papyrifera polysaccharide in preparation of a medicine for preventing or treating liver injury. The inventor establishes a mouse liver injury model through acetaminophen, and finds that pathological changes of the liver of a mouse given with the paper mulberry polysaccharide are obviously relieved, the levels of ALT, AST and inflammatory factors IL-6, IL-10 and TNF-alpha in serum of the mouse with liver injury are obviously reduced, the levels of GSH, GSH-Px, CAT and SOD in liver tissue are increased, accumulation of MDA is reduced, the content of CYP2E1 in the liver is reduced, and the effect of preventing and treating the liver injury is achieved. Meanwhile, the content of GST and SULT1A1 is increased, so that the detoxification capability of the liver on APAP metabolites is enhanced. In addition, the broussonetia papyrifera polysaccharide can regulate intestinal flora and maintai