Resonant nanophotonic biosensor

A metasurface is used to provide optical sensing of a biological target, the metasurface having a guided mode resonance with an electric field distribution extending from the metasurface. Surface functionalization of such metasurfaces can be used to provide sensing for biological targets such as nucleic acids, proteins, small molecules, extracellular vesicles, and whole cells. The combination of the target and the surface functionalization may affect the resonant wavelength of the guided mode resonance, thereby providing a sensitive assay for the biological target. 使用超表面来提供生物目标的光学感测，该超表面具有导模共振，该导模共振具有从该超表面延伸出来的电场分布。此类超表面的表面功能化可以被用于为诸如核酸、蛋白质、小分子、细胞外囊泡和全细胞之类的生物目标提供感测。目标与表面功能化的结合可以影响导模共振的共振波长，从而为生物目标提供灵敏的测定。