Octreotide-loaded polyethylene glycol modified mesoporous silica sustained-release nanoparticles as well as preparation method and application thereof

The invention provides octreotide-loaded polyethylene glycol modified mesoporous silica sustained-release nanoparticles as well as a preparation method and application thereof. According to the preparation method, PEG2000 is used as a modification material, soybean lecithin is used as a surfactant, MSNs are subjected to surface modification, octreotide is used as a drug, a composite nano mesoporous silica composite drug carrier is prepared, and the octreotide-loaded PEG modified MSNs sustained-release nanoparticles are obtained. The drug loading performance, including but not limited to the encapsulation efficiency and the drug loading capacity, of the nanoparticles can be improved. Meanwhile, toxic and side effects can be relieved, and bioavailability is improved. 本发明提供了一种负载奥曲肽聚乙二醇修饰介孔二氧化硅缓释纳米粒及其制备方法和应用。该制备方法利用PEG2000为修饰材料，大豆卵磷脂为表面活性剂，对MSNs进行表面修饰，以奥曲肽为药物，制备复合纳米介孔二氧化硅复合载药载体，即为负载奥曲肽PEG修饰MSNs缓释纳米粒。这能够提高纳米粒的载药性能，包括但不限于包封率、载药量。同时可以减轻毒副作用，提高生物利用度。