D-glucosamine fluoroquinolone derivative as well as preparation method and application thereof

Experiments prove that the D-glucosamine fluoroquinolone derivative has good anti-human pathogenic bacterium activity, the antibacterial activity of part of molecules is equivalent to or even higher than that of a positive control drug fluoroquinolone, and the antibacterial activity of all molecules is higher than that of a D-glucosamine derivative IM2; most molecules also have better anti-citrus canker pathogen activity, and the antibacterial activity of part of molecules is equivalent to or even stronger than that of a positive control drug streptomycin; part of molecules show very good development potential and can be used for preparing antibacterial drugs; the invention also discloses a preparation method of the D-glucosamine fluoroquinolone derivative, which has the advantages of few reaction steps, good selectivity and high yield. 本发明公开了一种D-氨基葡萄糖氟喹诺酮衍生物，经实验证实，其具有较好的抗人致病菌活性，部分分子的抗菌活性与阳性对照药物氟喹诺酮相当甚至更强，所有分子的抗菌活性强于D-氨基葡萄糖衍生物IM2；多数分子还具有较好的抗柑橘溃疡病菌活性，部分分子的抗菌活性与阳性对照药物链霉素相当甚至更强；部分分子显示非常好的开发潜力，可用于制备抗菌药物；本发明还公开了所述