N, N-dialkyl substituted nereistoin compounds and preparation method thereof

The invention discloses an N, N-dialkyl substituted nereistoin compound and a preparation method thereof, and belongs to the field of organic chemistry. According to the preparation method, N, N-dialkyl-1, 3-dichloropropane and phosphorothioate are used as raw materials, acetonitrile is used as a solvent under the alkaline condition, and the nereistom compound is prepared through a substitution reaction. The method has the advantages of mild conditions, easily available raw materials and simple operation. The prepared nereistoin compound takes a natural product nereistoxin as a lead compound, is modified by phosphorothioate with wide biological activity, and can be used in the aspects of biological medicines, pesticides and the like. 本发明公开了一类N，N-二烷基取代的沙蚕磷类化合物及其制备方法，属于有机化学领域。该制备方法以N，N-二烷基-1，3-二氯丙烷、硫代磷酸酯为原料，在碱性条件下，以乙腈为溶剂，通过取代反应制得该类沙蚕磷化合物。该方法条件温和、原料易得、操作简单。制备的沙蚕磷类化合物以天然产物沙蚕毒素为先导化合物，通过具有广泛生物活性的硫代磷酸酯加以修饰，可用于生物医药、农药等方面。