Application of polypeptide or composition thereof in prevention or treatment of cartilage-related diseases

The invention relates to the technical field of biological medicine, in particular to application of polypeptide or a composition thereof in prevention or treatment of cartilage-related diseases. The invention aims at discussing the treatment potential of histone-rich protein-1 in treatment of osteo...

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Bibliographische Detailangaben
Hauptverfasser: LI XINGYANG, ZHONG WENCHAO, ZHU MINGJING, ZHANG QINGBIN, CAO WEI, WU GANG, WU ANTONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the technical field of biological medicine, in particular to application of polypeptide or a composition thereof in prevention or treatment of cartilage-related diseases. The invention aims at discussing the treatment potential of histone-rich protein-1 in treatment of osteoarthrosis and revealing the potential mechanism of histone-rich protein-1. Through verification, the pathogenicity of the disease is relieved by injecting histone-rich protein-1 into the joint cavity of the rat. The histone-rich protein-1 shows a strong anabolism promoting effect on cartilage cells in an inflammatory environment state by enhancing proliferation, migration and cartilage differentiation and preventing apoptosis. Therefore, the histone-rich protein-1 can greatly relieve the bone joint injury and protect the bone joint structure and function by regulating the anabolism of cartilage cells. 本发明涉及生物医药技术领域,尤其是涉及多肽或其组合物在预防或治疗软骨相关疾病中的应用。本发明旨在探讨富组蛋白-1在骨关节病治疗中的治疗潜力,并揭示其潜在机制。经验证,大鼠关节腔内注射富组蛋白-1减轻了疾病的致病性。富组蛋白-1通过