Functionalized polypeptide derivative for inhibiting virus main protease as well as preparation method and application thereof

The invention relates to a functional polypeptide derivative for inhibiting virus main protease as well as a preparation method and application of the functional polypeptide derivative. The structure of the compound is shown as a formula (I). The invention also relates to a pharmaceutical compositio...

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Bibliographische Detailangaben
Hauptverfasser:	WANG YING, ZENG HONG, PAN DESI, LIU GANG, GONG XIAOMING, LU XIANPING, XIA SHANGHUA, ZHANG ZIKUO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a functional polypeptide derivative for inhibiting virus main protease as well as a preparation method and application of the functional polypeptide derivative. The structure of the compound is shown as a formula (I). The invention also relates to a pharmaceutical composition containing the compound as an active ingredient. The compound disclosed by the invention has relatively strong inhibitory activity on the main protease of the SARS-CoV-2 virus. 本发明涉及一种作为抑制病毒主蛋白酶的功能化多肽衍生物、其制备方法及其应用。所述化合物的结构如式(I)所示。本发明还涉及包含所述化合物作为活性成分的药物组合物。本发明化合物对SARS-CoV-2病毒主蛋白酶具有较强的抑制活性。